ArticleMolecular biology reports2026
Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOrmeloxifene (ORM), a selective estrogen receptor modulator with a non-steroidal structure, exhibits mild estrogenic activity in bone and anti-estrogenic activity in uterine and breast tissues. ORM induces cell-cycle arrest and exhibits antineoplastic activity in breast cancer. However, its direct effect on the cellular senescence phenotype has not been documented. METHODS AND
resultsTwo-dimensional gel electrophoresis (2DE)-based proteomic analysis of ORM-treated MDA-MB-231 cells identified differentially regulated proteins by MALDI-TOF/TOF mass spectrometry. Functional categorization and pathway-level integration of these proteins suggested a coordinated cellular response converging on stress-induced cellular senescence. MTT, colony formation, cell-cycle, β-galactosidase and Sudan Black B staining, and immunoblotting were performed to investigate ORM-induced senescence. ORM inhibited viability of MCF7 and MDA-MB-231 cells, with IC
conclusionsCollectively, these findings suggest that ORM restrains tumor progression by promoting irreversible senescence. The combination of ORM and tamoxifen may represent a potential therapeutic strategy for tamoxifen-resistant breast tumors.
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