ArticleMolecular neurobiology2026
Epiregulin Mitigates Type 2 Diabetes-associated Cognitive Dysfunction by Inhibiting Hippocampal Neuronal Ferroptosis via the Nrf2 Pathway.
Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To investigate whether epiregulin (EREG) mitigates type 2 diabetes-associated cognitive dysfunction (T2DM-ACD) by inhibiting hippocampal ferroptosis via the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. T2DM mice received EREG or vehicle for 4 weeks. Cognitive function was assessed by Morris water maze. Hippocampal neuronal damage was evaluated by Nissl staining, and ferroptosis-related protein expression was assessed by immunofluorescence. Transcriptomic profiling was performed by RNA sequencing in HT22 cells under control, high-glucose, and EREG-treated conditions. HT22 hippocampal neurons were exposed to high glucose with or without EREG, and the Nrf2 inhibitor ML385 was added to verify pathway dependency. Mitochondrial ultrastructure was observed by transmission electron microscopy. Ferroptosis-related indices, including lipid reactive oxygen species (lipid ROS), malondialdehyde (MDA), glutathione (GSH), and intracellular ferrous iron (Fe
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