ArticleWorld journal of microbiology & biotechnology2026
Isoelectric point stabilization and protein mass compression are associated with antimicrobial resistance in the genus Acinetobacter.
Article in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe genus Acinetobacter is widely regarded as a major reservoir of antimicrobial resistance (AMR); however, the evolutionary distribution of resistance across the genus remains unclear. This study aimed to investigate phylogenomic structure and associated proteomic features underlying AMR distribution.
methodsA total 67 genomes including 65 representative Acinetobacter species, one additional Acinetobacter baumannii ATCC 19606 reference genome and Alkanindiges hydrocarboniclasticus as the outgroup were analyzed using a 174-gene core genome phylogeny. Resistome profiling was performed using homology-based screening, and proteome-wide properties, including isoelectric point (pI), molecular weight, and protein count, were statistically compared between antibiotic resistance gene (ARG) positive and ARG negative groups based on Resfinder Screening.
resultsPhylogenetic analysis revealed a clear partitioning into ARG positive and ARG negative clades with 28 lineages lacking detectable AMR determinants. A Chi-square test confirmed a significant association between evolutionary clades and resistome distribution (X2 = 29.69, p = 0.0052). While global pI values remained conserved, ARG positive lineages showed significantly reduced pI variance (p = 0.0054). Additionally, ARG positive lineages exhibited expanded proteomes (p < 0.0001) coupled with reduced average molecular weight (p = 0.0056), indicating a shift toward a more compact proteome architecture.
conclusionThese findings suggest that AMR evolution in Acinetobacter is associated with both genomic partitioning and distinct proteomic patterns. The presence of ARG-negative lineages and coordinated differences in proteome size, average molecular weight, and pI variance highlight the potential role of biophysical properties in shaping AMR-associated genomic variation, while the conserved global pI indicates that these differences do not reflect a shift in overall proteome pI. These findings provide a framework for further investigating biophysical features associated with emerging ARG-positive lineages.
Indexed as
Identifiers
42821028What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.