Unifying orientation-dependent relaxation and diffusion around axonal fibers in DTI: characterizing fiber-tract-specific anisotropic R

Yuxi Pang, Rajikha Raja, Wilburn E Reddick

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Article in Brain structure & function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Yuxi PangDepartment of Radiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 220, Memphis, TN, 38105, USA. yuxi.pang@stjude.org.ORCID http://orcid.org/0000-0001-5039-0236

Rajikha RajaDepartment of Radiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 220, Memphis, TN, 38105, USA.

Wilburn E ReddickDepartment of Radiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 220, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0002-1054-1201

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6 · The paper itself

Abstract

This work aims to characterize fiber-tract-specific, orientation-dependent [Formula: see text] values across seven callosal segments (CC1[Formula: see text]CC7) using high-resolution diffusion tensor imaging (DTI) datasets from the Human Connectome Project. White matter (WM) voxels within each segment were identified using jointly applied thresholds of fractional anisotropy (FA) and mode of anisotropy (MO) to ensure robust selection of coherently oriented fibers. Orientation-dependent [Formula: see text] profiles were then derived from T2W images (b = 0), incorporating voxel-wise principal fiber orientations. These profiles were modeled using a cone-based framework that captures directional variations in transverse relaxation, enabling a clean separation of the magnitude of anisotropic [Formula: see text] component ([Formula: see text]) from its isotropic counterpart. Across segments, fits obtained at different b-values showed no major discrepancies aside from changes in [Formula: see text]. On average, [Formula: see text] increased from 2.4 ± 0.2 s

Indexed as

AxonsCorpus CallosumDiffusion Tensor ImagingWhite MatterAnisotropyConnectomeHumansImage Processing, Computer-AssistedNeural PathwaysAnisotropic translational diffusionAnisotropic transverse relaxationCorpus callosumDiffusion tensor imagingRelaxometry-diffusionT2-weighted image

Identifiers

PMID42820975

DOI10.1093/brain/112.3.799

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.