Evidence map›Paper›PMID 42820970›Full record

ArticleDiabetologia2026

Efficacy of the digital therapeutic glucura combined with CGM in the treatment of type 2 diabetes: a randomised controlled trial over 6 months.

Guido Freckmann, Inke R König, Hanna Grube, Maren Vens, Oliver Witt, Vanessa Kappelmeier, Kim L Pethahn, Christian Sina, Othmar Moser, Torsten Schröder

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Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guido FreckmannInstitut für Diabetes-Technologie Ulm GmbH, Ulm, Germany.ORCID http://orcid.org/0000-0002-0406-9529
Inke R KönigInstitut für Medizinische Biometrie und Statistik, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0003-0504-6465
Hanna GrubeInstitut für Medizinische Biometrie und Statistik, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0003-3179-7895
Maren VensInstitut für Medizinische Biometrie und Statistik, University of Lübeck, Lübeck, Germany.
Oliver WittPerfood Laboratories GmbH, Research & Development, Lübeck, Germany.ORCID http://orcid.org/0009-0000-8665-9137
Vanessa KappelmeierPerfood Laboratories GmbH, Research & Development, Lübeck, Germany.
Kim L PethahnPerfood Laboratories GmbH, Research & Development, Lübeck, Germany.
Christian SinaInstitute of Nutritional Medicine, University Hospital Schleswig-Holstein, Lübeck Campus & University of Lübeck, Lübeck, Germany.
Othmar MoserExercise Physiology, Training and Training Therapy Research Group, Institute of Human Movement Science, Sport and Health, University of Graz, Graz, Austria.
Torsten SchröderPerfood Laboratories GmbH, Research & Development, Lübeck, Germany. torsten.schroeder@perfood.de.ORCID http://orcid.org/0009-0006-4897-1481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisCGM is increasingly recommended for non-insulin-treated type 2 diabetes according to the ADA Standards of Care 2026. However, its clinical benefit in high-quality standard care remains limited. This study evaluated whether addition of the digital therapeutic glucura, which delivers personalised lifestyle intervention and self-management guidance, improves glycaemic outcomes beyond CGM and standard care.

methodsThe study was a 6-month, multicentre, open-label RCT conducted at 24 sites in Germany (ID: DRKS00032537). Adults (≥18 years) with non-insulin-treated type 2 diabetes (HbA

resultsOf 327 randomised participants (intervention: n=165; control: n=162), 320 were analysed (ITT population). The standalone CGM control group improved HbA CONCLUSIONS/

interpretationIn non-insulin-treated type 2 diabetes, CGM plus standard care yielded less metabolic benefit than CGM combined with glucura. The combination of glucura and CGM also translated into improvements beyond glycaemic management. Trial registration German Clinical Trials Register DRKS00032537 Funding The study was funded by Perfood Laboratories GmbH.

Indexed as

CGMContinuous glucose monitoringDigital therapeuticDTxGlucuraLifestyle treatmentLow-glycaemic diet

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.