Evidence map›Paper›PMID 42820923›Full record

ArticleCNS neuroscience & therapeutics2026

Brain-Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus.

Yaxin Hao, Xiang Zhang, Danyang Zhao, Haixing Zhong, Yongqiang Chen, Heming Li, Minghui Ren, Mengchu Zhu, Fang Yuan

Abstract read
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In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yaxin HaoDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.
Xiang ZhangDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0009-0001-5302-3252
Danyang ZhaoDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.
Haixing ZhongDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yongqiang ChenDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0009-0001-7174-6534
Heming LiDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.
Minghui RenDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.
Mengchu ZhuDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0009-0004-8340-0305
Fang YuanDepartment of Neurobiology, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0000-0002-2590-1572

Funding

Graduate Innovation Funding Program of Hebei Province CXZZBS2024114Hebei Province Yanzhao Golden Platform Project HJZD202510National Natural Science Foundation of China 32671478National Natural Science Foundation of China 82170104Natural Science Foundation of Hebei Province H2025206880
6 · The paper itself

Abstract

objectiveThe dorsomedial hypothalamus (DMH) integrates metabolism and autonomic homeostasis, but whether subnuclear functional topography exists remains unclear. This study compared whole-brain input-output connectomes of leptin receptor (LepRb) neurons in dorsal DMH (DMD) versus DMH to test for connection-biased segregation.

methodsRabies monosynaptic retrograde tracing and Cre-dependent AAV anterograde tracing in LepRb-Cre mice mapped and quantified input-output projections of DMD

resultsBoth DMD

conclusionDMD

Indexed as

NeuronsReceptors, LeptinAnimalsBrain MappingHypothalamusMaleMiceMice, TransgenicNeural PathwaysReceptors, Leptinconnectivity biasdorsal part of the DMHdorsomedial hypothalamusleptin receptorneural circuitry

Identifiers

PMID42820923
PMCPMC13629605

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.