ArticleJournal of veterinary internal medicine2026
Influence of including or excluding endocardial borders on left ventricular wall thickness measurements in cats.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundConsensus is lacking on which endocardial borders to include when measuring left ventricular wall thickness (LVWT) in cats. HYPOTHESIS/
objectivesThe number of endocardial borders included can influence whether an individual cat is classified as having hypertrophic cardiomyopathy (HCM) or not. ANIMALS: Fifty-two cats that previously were diagnosed as either healthy, equivocal for HCM, or having an HCM phenotype.
methodsSingle-center retrospective cross-sectional study. Three observers measured LVWT using 4 different LVWT measurement protocols: leading edge-to-leading edge (L-L); leading edge-to-trailing edge, trailing edge-to-leading edge, and trailing edge-to-trailing edge for the interventricular septum and L-L and trailing edge-to-leading edge methods for the left ventricular free wall (LVFW). Measurements were made using stored echocardiographic images on 2 occasions by 2 observers. A Friedman test and post-hoc Wilcoxon signed rank test with Bonferroni correction were performed to detect differences between measurement techniques.
resultsInterventricular septum (IVS) wall thickness was significantly larger for leading-edge-to-trailing-edge measurement (median and [interquartile range (IQR)]: 5.5 [3.8-7.2] millimeters) compared with other methods (P < .001). The trailing-edge-to-leading-edge method produced significantly smaller results (4.3 [IQR, 3.4-6.2] millimeters for the interventricular septum and 4.8 [IQR, 3.4-6.2] millimeters for the LVFW) compared with other methods (P < .001). Median IVS thickness measured as leading-edge-to-trailing-edge was 1.2 millimeters larger than when measured as trailing-edge-to-leading-edge. CONCLUSIONS AND CLINICAL IMPORTANCE: LVWT varies depending on the number of endocardial borders included. The number of endocardial borders included in LVWT measurements should be standardized.
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