Evidence map›Paper›PMID 42820640›Full record

ArticleCartilage2026

Inhibition of Hexokinase 2 Undermines Cartilage Health and Accelerates Osteoarthritis.

Haokun Xu, Xinyi Zhang, Yijie Fu, Genming Liu, Daizhao Deng, Feibi Ren, Sirui Yuan, Ying Lin, Ruijun Lai, Kai Li and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haokun XuDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Xinyi ZhangDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Yijie FuDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Genming LiuDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Daizhao DengDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Feibi RenDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Sirui YuanDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Ying LinDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Ruijun LaiGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Kai LiGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Tinghui XiaoOrthopedic Department, Shenzhen People's Hospital, Shenzhen, China.
Song XuNanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiaochun BaiDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Yue ZhangDepartment of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, China.ORCID 0000-0002-6612-8002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveEnhanced glycolysis is a metabolic hallmark of chondrocytes in osteoarthritis (OA); however, the roles of the glycolytic rate-limiting enzyme hexokinase 2 (HK2) in cartilage remain poorly understood.MethodsMice and cell models involving HK2 knockout in Col2a1-expressing chondrocytes and 3-bromopyruvate (3-BrPA) treatment are utilized to assess the potential impact of HK2 blockage on cartilage

Indexed as

CalcificationChondrocyteCol2a1-CreHexokinase 2Osteoarthritis

Identifiers

PMID42820640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.