Evidence map›Paper›PMID 42820306›Full record

ArticleThe Journal of clinical investigation2026

Tie1 ectodomain cleavage governs vascular responses to inflammatory stimulation but is dispensable for angiogenic signaling.

Miki Kamiyama, Jingjing Shi, Lorna Rinck, Yanzhu Lin, Yifang Mao, Xiaowen Zhang, Ashik Ahmed Abdul Pari, Stephanie F Preuss, Marlene Hoffarth, Gladys Hofsetz and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Miki KamiyamaEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jingjing ShiEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Lorna RinckEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Yanzhu LinEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Yifang MaoEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Xiaowen ZhangEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Ashik Ahmed Abdul PariEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Stephanie F PreussEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marlene HoffarthEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gladys HofsetzEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Yuxi DiEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Asmaa ZahranEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Carleen SpeggGerman Cancer Research Center, Heidelberg, Germany.
Maria RiedelGerman Cancer Research Center, Heidelberg, Germany.
Donato InversoEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Roxana OlaEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Junhao HuShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Kari AlitaloWihuri Research Institute, University of Helsinki, Helsinki, Finland.
Hellmut G AugustinEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Mahak SinghalEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental vascular programs.

Indexed as

AngiogenesisInflammationNeovascularization, PhysiologicReceptor, TIE-1Signal TransductionAnimalsHumansMiceProtein DomainsReceptor, TIE-1AngiogenesisInflammationSignal transductionVascular biology

Identifiers

PMID42820306
PMCPMC13626837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.