Evidence map›Paper›PMID 42820257›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Endothelial Exostosin-1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury.

Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura and 13 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yuki KawasakiDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Hiroyuki TomitaDepartment of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
Kodai SuzukiDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Chihiro TakadaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Hirotaka AsanoDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Soichiro KanoDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Yugo WakayamaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Hirotsugu FukudaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Toru MinamiyamaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Genki YoshimuraDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Ryo KamidaniDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Yoshinori KakinoDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Tomotaka MiuraDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Yuichiro KitagawaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Tetsuya FukutaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Takahito MiyakeDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Akio SuzukiDepartment of Pharmacy, Gifu University Hospital, Gifu, Japan.
Kazu MatsumotoDepartment of Internal Medicine, Gifu Seiryu Hospital, Gifu, Japan.
Nobuyuki TetsukaDepartment of Infection Control, Gifu University Graduate School of Medicine, Gifu, Japan.
Shozo YoshidaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Yoichi MaekawaDepartment of Parasitology and Infectious Diseases, Gifu University Graduate School of Medicine, Gifu, Japan.
Yu YamaguchiHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Hideshi OkadaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.ORCID https://orcid.org/0000-0001-6280-677X

Funding

Microglial heparan sulfate in the modulation of APOE function and neurodegenerationR01AG072468 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI YU YAMAGUCHI · 2022 to 2026
$2.9M
Foundation for the National Institutes of Health (FNIH) 1R01AG072468JST FOREST PROGRAM JPMJFR220WMEXT | Japan Society for the Promotion of Science (JSPS) 20K07587MEXT | Japan Society for the Promotion of Science (JSPS) 20K17856MEXT | Japan Society for the Promotion of Science (JSPS) 21K16570MEXT | Japan Society for the Promotion of Science (JSPS) 22H03171MEXT | Japan Society for the Promotion of Science (JSPS) 23H03326MEXT | Japan Society for the Promotion of Science (JSPS) 23K15612MEXT | Japan Society for the Promotion of Science (JSPS) 23K18311MEXT | Japan Society for the Promotion of Science (JSPS) 24K02545MEXT | Japan Society for the Promotion of Science (JSPS) 24K12174MEXT | Japan Society for the Promotion of Science (JSPS) 24K19484MEXT | Japan Society for the Promotion of Science (JSPS) 25K02742MEXT | Japan Society for the Promotion of Science (JSPS) 25K12267MEXT | Japan Society for the Promotion of Science (JSPS) 25K19629NIA NIH HHS R01 AG072468
6 · The paper itself

Abstract

The endothelial glycocalyx depends on Exostosin-1 (Ext1)-mediated heparan sulfate synthesis; however, its endothelial cell-autonomous role in acute inflammation remains unclear. Therefore, we examined the role of Ext1 during acute inflammation. In this study, endothelial-specific Ext1-deficient mice (Ext1

Indexed as

Acute Lung InjuryEndothelial CellsGlycocalyxInflammationN-AcetylglucosaminyltransferasesAnimalsExostosin 1Heparan SulfateMaleMiceMice, Inbred C57BLMice, KnockoutExostosin 1Heparan SulfateN-Acetylglucosaminyltransferasesendothelial cellsexostosin‐1glycocalyxinflammationmicrocirculation

Identifiers

PMID42820257
PMCPMC13628440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.