Evidence map›Paper›PMID 42820243›Full record

ArticleiScience2026

Distinct tumor microenvironment profiles characterize regressive versus progressive anal precancers.

Fernando Dias Goncalves Lima, Marieke E Ijsselsteijn, Johanna F Verkerk, Kirsten Rozemeijer, Carel J M van Noesel, Noel F C C de Miranda, Jan M Prins, Rosalie M Luiten, Renske D M Steenbergen, Henry J C de Vries

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fernando Dias Goncalves LimaAmsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Boelelaan 1117, Amsterdam, the Netherlands.
Marieke E IjsselsteijnLeiden University Medical Center, Department of Pathology, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Johanna F VerkerkAmsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Boelelaan 1117, Amsterdam, the Netherlands.
Kirsten RozemeijerAmsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Boelelaan 1117, Amsterdam, the Netherlands.
Carel J M van NoeselAmsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Boelelaan 1117, Amsterdam, the Netherlands.
Noel F C C de MirandaLeiden University Medical Center, Department of Pathology, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Jan M PrinsAmsterdam Institute for Immunology & Infectious Diseases (AI&I), Amsterdam, the Netherlands.
Rosalie M LuitenCancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands.
Renske D M SteenbergenAmsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Boelelaan 1117, Amsterdam, the Netherlands.
Henry J C de VriesAmsterdam UMC, Location University of Amsterdam, Department of Dermatology, Meibergdreef 9, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncogenesis of anal high-grade squamous intraepithelial lesions (HSIL) is highly variable. Therefore, all HSIL are ablated, leading to overtreatment and associated burden because not all lesions will progress to cancer. This exploratory study investigated differences in the tumor immune microenvironment between regressive and progressive HSIL in people living with HIV to enable a more tailored approach. Multiplex imaging mass cytometry showed more inflammation in HSIL that progressed to cancer and cancer samples, compared with HSIL that spontaneously regressed and controls. Densities of HLA-DR

Indexed as

anal cancerhigh-grade squamous intraepithelial lesionsHIVHPVHSILhuman immunodeficiency virushuman papillomavirusimaging mass cytometryimmunofluorescencemacrophage polarizationtumor immune microenvironment

Identifiers

PMID42820243
PMCPMC13626763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.