Evidence map›Paper›PMID 42820225›Full record

ArticleArchives of internal medicine research2026

An Overview of IgG4-Related Disease.

Amy Phu, Lannhi Nguyen, Daniel Mashiach, Ryan Afrahim, Devendra K Agrawal

Abstract read
In one paragraph

Article in Archives of internal medicine research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amy PhuDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Lannhi NguyenDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Daniel MashiachDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Ryan AfrahimDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Devendra K AgrawalDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.ORCID 0000-0001-5445-0013

Funding

Research Education Program to Promote Diversity in Immunologic and Allergic DiseasesR25AI179582 · NIAID · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI Devendra K. Agrawal · 2025 to 2026
$756k
NIAID NIH HHS R25 AI179582
6 · The paper itself

Abstract

IgG4-related disease is a chronic inflammatory condition that has been formally described and extensively researched only in the recent few decades, making it a relatively new clinical entity. Furthermore, IgG4- related disease has been highly underreported and misdiagnosed as other similarly presenting conditions. In this article, we discuss the variable presentation, diagnosis process and criteria of IgG4-related disease and Sjogren's syndrome in consideration of the literature currently available. In IgG4- related disease patients, an accurate diagnosis is crucial to timely treatment and circumvention of serious adverse outcomes such as irreversible organ damage. This critical review article provides an overview of IgG4-related disease with a primary focus on (i) current understanding of its pathophysiological mechanisms, (ii) most recognized clinical phenotypes, (iii) current diagnostic guidelines, and (iv) current treatments available.

Indexed as

Autoimmune hepatitisDacryoadenitisImmunoglobulin g4-related diseaseParotitisSialadenitisSubmandibular swelling

Identifiers

PMID42820225
PMCPMC13626708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.