Evidence map›Paper›PMID 42820169›Full record

ArticleProceedings of machine learning research2026

Contrastive Diffusion Alignment: Learning Structured Latents for Controllable Generation.

Ruchi Sandilya, Sumaira Perez, Charles Lynch, Lindsay Victoria, Benjamin Zebley, Derrick Matthew Buchanan, Mahendra T Bhati, Nolan Williams, Timothy J Spellman, Faith M Gunning and 2 more

Abstract read
In one paragraph

Article in Proceedings of machine learning research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruchi SandilyaDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Sumaira PerezDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Charles LynchDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Lindsay VictoriaDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Benjamin ZebleyDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Derrick Matthew BuchananDepartment of Psychiatry, Stanford University, Stanford, CA, USA.
Mahendra T BhatiDepartment of Psychiatry, Stanford University, Stanford, CA, USA.
Nolan WilliamsDepartment of Psychiatry, Stanford University, Stanford, CA, USA.
Timothy J SpellmanDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.
Faith M GunningDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Conor ListonDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Logan GrosenickDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.

Funding

Efficacy of biomarker-guided rTMS for treatment resistant depressionR01MH118388 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI BHATI, MAHENDRA T, GUNNING, FAITH M · 2019 to 2025
$6.2M
Reproducibility statistics and machine learning methods for systematic phenotyping and model integration across animals, organs, and technologiesR01OD039830 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI GROSENICK, LOGAN · 2025 to 2025
$3.3M
Scalable Biomarkers and Generative Digital Twins for Personalized Neurostimulation in DepressionR01MH131534 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LOGAN GROSENICK · 2022 to 2026
$3.2M
NIH HHS R01 OD039830NIMH NIH HHS R01 MH118388NIMH NIH HHS R01 MH131534Wellcome Trust
6 · The paper itself

Abstract

Diffusion models excel at generation, but their latent spaces are high dimensional and not explicitly organized for interpretation or control. We introduce ConDA (Contrastive Diffusion Alignment), a plug-and-play geometry layer that applies contrastive learning to pretrained diffusion latents using auxiliary variables (e.g., time, stimulation parameters, facial action units). ConDA learns a low-dimensional embedding whose directions align with underlying dynamical factors, consistent with recent contrastive learning results on structured and disentangled representations. In this embedding, simple nonlinear trajectories support smooth interpolation, extrapolation, and counterfactual editing while rendering remains in the original diffusion space. ConDA separates editing and rendering by lifting embedding trajectories back to diffusion latents with a neighborhood-preserving kNN decoder and is robust across inversion solvers. Across fluid dynamics, neural calcium imaging, therapeutic neurostimulation, facial expression dynamics, and monkey motor cortex activity, ConDA yields more interpretable and controllable latent structure than linear traversals and conditioning-based baselines, indicating that diffusion latents encode dynamics-relevant structure that can be exploited by an explicit contrastive geometry layer.

Identifiers

PMID42820169
PMCPMC13626448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.