ReviewCureus2026
Melanocyte-Fibroblast Crosstalk Under Visible Light and Infrared-A Exposure: A Narrative Review of Implications for Photoaging and Dyschromia.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solar radiation extends beyond the ultraviolet spectrum to include visible light and infrared-A wavelengths, which have traditionally been considered biologically inert. Emerging evidence indicates that these longer wavelengths act both independently and in combination to influence communication between skin cells, contributing meaningfully to photoaging and pigmentary changes. This narrative review synthesizes existing peer-reviewed research on how visible light and infrared-A radiation alter signaling between dermal and epidermal cells and how these alterations may underlie disorders of pigmentation and structural skin aging. A structured search of PubMed and Scopus (January 2016-June 2026) was conducted to identify English-language, peer-reviewed studies examining the mechanisms by which these wavelengths affect skin cell biology and intercellular communication, encompassing in vitro, ex vivo, animal, and clinical research. The synthesized findings indicate that visible light and infrared radiation jointly influence cellular signaling pathways that govern pigment production, breakdown of the skin's structural matrix, and cellular aging processes. Accumulating, predominantly preclinical evidence suggests that these wavelengths should no longer be overlooked in the study of skin biology's response to sunlight. Accumulating evidence points to distinct and overlapping mechanisms by which each spectral range promotes cellular aging, structural matrix changes, and disruption of the signaling molecules that dermal cells use to regulate pigment-producing cells in the skin's outer layer. This disruption alters key communication factors that drive overactivation of pigment cells, resulting in uneven pigmentation. A separate mechanism, independent of this cell-to-cell communication pathway, involves direct activation of pigment-producing cells by visible light through a distinct cellular signaling cascade. These findings suggest that broadening photoprotection beyond the ultraviolet range may be a reasonable strategy, while also identifying candidate, largely investigational therapeutic targets for addressing photoaging and pigmentary disorders that require further clinical study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.