Evidence map›Paper›PMID 42820127›Full record

ArticleRegenerative biomaterials2026

UV-grafted polyitaconic acid functionalization of PEEK promotes osteoimmunomodulation and osseointegration with PI3K-AKT-associated autophagy regulation.

Liping Zhou, Yang Zhou, Changyue Liu, Xiangyu Li, Chen Wu, Hanling Deng, Wenjiao Zeng, Yongheng Zhang, Ying Liu, Lvhua Liu and 3 more

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liping ZhouSchool of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.
Yang ZhouDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Changyue LiuDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Xiangyu LiDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Chen WuDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Hanling DengSchool of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.
Wenjiao ZengSchool of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.
Yongheng ZhangDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Ying LiuDepartment of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Lvhua LiuSchool of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.
Ang GaoCenter for AI-Driven Medical Research, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Huaiyu WangCenter for AI-Driven Medical Research, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Yanyan ZhengSchool of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyetheretherketone (PEEK) is a promising orthopedic implant material because of its favorable mechanical properties and biocompatibility, yet its bioinert surface limits osseointegration. Here, we develop a polyitaconic acid-functionalized PEEK surface (PEEK-PITAc) through a one-step ultraviolet-induced graft polymerization strategy to improve its osteoimmunomodulatory performance. The PITAc-grafted PEEK surface exhibits enhanced hydrophilicity and bioactivity while maintaining its original morphology.

Indexed as

itaconic acidosseointegrationosteoimmunomodulationpolyetheretherketonesurface modification

Identifiers

PMID42820127
PMCPMC13626135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.