Evidence map›Paper›PMID 42820100›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2026

Oxygen extraction fraction mapping between normal cognition and mild cognitive impairment in older adults using quantitative BOLD.

Linh N N Le, Gregory J Wheeler, Nicholas P Blockley, Evan Fletcher, Youngkyoo Jung, Sarah E T Farias, Brandon Gavett, Charles DeCarli, Audrey P Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linh N N LeDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0000-0002-5920-9920
Gregory J WheelerDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0000-0002-9545-1175
Nicholas P BlockleySchool of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0003-2595-8285
Evan FletcherDepartment of Neurology, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0000-0002-9761-3131
Youngkyoo JungDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0000-0002-7236-8897
Sarah E T FariasDepartment of Neurology, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0009-0009-8969-3387
Brandon GavettDepartment of Neurology, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0000-0003-1938-1854
Charles DeCarliDepartment of Neurology, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0000-0003-1914-2693
Audrey P FanDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.ORCID https://orcid.org/0000-0001-5850-6117

Funding

The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints (INDEED)U19NS120384 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli · 2020 to 2026
$61.9M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
Imaging of brain oxygen extraction fraction in vascular contributions to dementiaR01NS128179 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Audrey Peiwen Fan · 2023 to 2026
$2.6M
NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG031563NINDS NIH HHS R01 NS128179NINDS NIH HHS U19 NS120384
6 · The paper itself

Abstract

Oxygen extraction fraction (OEF) represents the proportion of oxygen utilized by the brain from the blood and is a sensitive biomarker in understanding the vascular interplay between oxygen supply and demand. Alterations in OEF are increasingly recognized in normal aging and the pathophysiology of many neurological disorders, including Alzheimer's disease and cognitive impairment. Here, we aimed to assess regional OEF MRI in older adults and investigate its relationship with mild cognitive impairment (MCI) and normal aging using a Variational Bayesian quantitative BOLD (qBOLD) framework. The qBOLD model leverages a biophysical relationship between OEF, deoxygenated blood volume (DBV), and the reversible transverse relaxation rate (R

Indexed as

AgingBrainCognitionCognitive DysfunctionMagnetic Resonance ImagingOxygenAgedAged, 80 and overBayes TheoremBrain MappingFemaleHumansMaleOxygenBayesian inferencemagnetic resonance imaging (MRI)mild cognitive impairment (MCI)oxygen extraction fraction (OEF)oxygen metabolismquantitative BOLD (qBOLD)

Identifiers

PMID42820100
PMCPMC13626017

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.