ArticleInfection and drug resistance2026
Rapid Succession of Multidrug-Resistant Bacteremia and Candidemia in a Patient with Refractory Pemphigus Vulgaris: A Lethal Therapeutic Challenge.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immunosuppressed patients with extensive skin barrier disruption face extraordinary risks for polymicrobial infections. The rapid, sequential emergence of multidrug-resistant (MDR) bacteremia and candidemia in such hosts constitutes a particularly lethal complication with limited therapeutic options. Case Presentation: We report a 74-year-old woman with refractory pemphigus vulgaris (PV), type 2 diabetes mellitus, and chronic obstructive pulmonary disease who developed a cascade of MDR infections over a 14-day hospitalization. Following initial methicillin-resistant Conclusion: This case starkly illustrates the catastrophic potential of rapid, sequential MDR infections in profoundly immunocompromised hosts with skin barrier defects. It underscores the critical importance of early microbiological surveillance, the clinical urgency of dynamic antimicrobial stewardship, and the imperative for multidisciplinary management to navigate the irreconcilable conflict between necessary immunosuppression and life-threatening infection.
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