ArticleRSC advances2026
Analytical quality-by-design-assisted RP-HPLC method for simultaneous determination of cinnamaldehyde and chrysin in a lipid-based delivery system and its greenness assessment.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An analytical quality-by-design (AQbD)-assisted reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the simultaneous determination of cinnamaldehyde (CN) and chrysin (CR) in a lipid-based delivery system. The CN : CR ratio was initially selected based on glucose utilisation studies in insulin-resistant HepG2 cells and Chou-Talalay combination index analysis, which identified a 1 : 1 ratio as most favourable. Chromatographic conditions were systematically optimised using a central composite design (CCD), with wavelength, aqueous-phase composition, pH, flow rate, and column temperature as critical method parameters. The optimised method employed methanol:acetonitrile : 0.1% orthophosphoric acid (40 : 40 : 20, v/v/v; pH 3.0; flow rate 0.8 mL min
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