Evidence map›Paper›PMID 42819887›Full record

ReviewRSC chemical biology2026

Bioorthogonal chemistry for deciphering lipid biology in living systems.

Brenda Portasany, Federica A Souto-Trinei, Roberto J Brea

Abstract readReview
In one paragraph

Review in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brenda PortasanyBioinspired Nanochemistry (BioNanoChem) Group, CICA - Centro Interdisciplinar de Química e Bioloxía, Departamento de Química, Facultad de Ciencias, Universidade da Coruña, Rúa As Carballeiras s/n, Campus de Elviña 15071 A Coruña Spain roberto.brea@udc.es.ORCID https://orcid.org/0009-0000-1733-2288
Federica A Souto-TrineiBioinspired Nanochemistry (BioNanoChem) Group, CICA - Centro Interdisciplinar de Química e Bioloxía, Departamento de Química, Facultad de Ciencias, Universidade da Coruña, Rúa As Carballeiras s/n, Campus de Elviña 15071 A Coruña Spain roberto.brea@udc.es.ORCID https://orcid.org/0000-0003-1785-6078
Roberto J BreaBioinspired Nanochemistry (BioNanoChem) Group, CICA - Centro Interdisciplinar de Química e Bioloxía, Departamento de Química, Facultad de Ciencias, Universidade da Coruña, Rúa As Carballeiras s/n, Campus de Elviña 15071 A Coruña Spain roberto.brea@udc.es.ORCID https://orcid.org/0000-0002-0321-0156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipids are among the most structurally diverse classes of biomolecules and play fundamental roles in membrane organization, energy storage, and cellular signalling. However, unlike proteins and nucleic acids, they are not directly encoded by the genome, making their selective visualization, manipulation, and functional interrogation in living systems particularly challenging. Over the past two decades, bioorthogonal chemistry has transformed lipid research by enabling the incorporation of minimally perturbing chemical reporters and the use of highly selective ligation reactions in complex biological environments. These advances have made it possible to synthesize, label, image, quantify, and manipulate lipids with unprecedented spatial and temporal precision. In this review, we discuss how bioorthogonal chemistry has expanded the experimental toolkit for deciphering lipid biology, highlighting applications ranging from the

Identifiers

PMID42819887
PMCPMC13625287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.