ArticleACS omega2026
Electrochemical Immunosensor for Point-of-Care Detection of Citrullinated Histone H3 Using Screen-Printed Graphene Electrodes and a Portable Potentiostat.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
Citrullinated histone H3 (CitH3) is an emerging biomarker for early sepsis diagnosis. However, its detection based on standard enzyme-linked immunosorbent assay (ELISA) suffers from long analysis time (4-5 h), expensive instruments, and the need for skilled operators, necessitating the development of alternative detection platforms. Herein, a portable electrochemical immunosensor for CitH3 determination was developed using a screen-printed graphene electrode coupled with a custom-designed potentiostat. CitH3 was detected via a sandwich immunoassay employing horseradish peroxidase-conjugated antibody and amperometric measurement in the presence of hydroquinone and hydrogen peroxide. Key fabrication and detection parameters were systematically optimized to achieve high analytical performance. Under optimal conditions, the immunosensor exhibited a linear detection range of 0.1-1000 ng mL
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