ArticleACS omega2026
GelMA-Based Hydrogels for Controlled Delivery of Antimicrobial Peptides against
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
Funding
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Abstract
objectiveThis study aimed to engineer and characterize GelMA hydrogels and dual-cross-linked GelMA-alginate hydrogels as tunable delivery platforms for antimicrobial peptides (AMPs; Histatin-5, GK-17, and INLK), and to evaluate their physicochemical properties, release kinetics, cytocompatibility, and antibiofilm efficacy against
methodsHydrogels with varying GelMA concentrations (5%, 7.5%, and 10%), with or without alginate, were fabricated and characterized in terms of microstructure, rheological and mechanical properties, swelling, degradation, and AMP release kinetics. Cytocompatibility was assessed using human gingival fibroblasts, and antimicrobial activity was evaluated through colony-forming unit counts, metabolic activity assays, biomass quantification, and confocal microscopy.
resultsAll hydrogels exhibited suitable moldability, pseudoplastic behavior, and structural stability. Increasing GelMA concentration and alginate incorporation enhanced mechanical properties: G10 displayed a higher compressive modulus (12,437.39 ± 565.33 Pa;
conclusionGelMA-based hydrogels provide a tunable and biocompatible platform for controlled AMP delivery, enabling effective disruption of
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Registered trials
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