ArticleACS omega2026
Investigating the Interaction between a Lipophilic Bioactive Compound and Digestive Enzymes via Interference Effects in Colloidal Crystal Films.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Curcumin, as an example of a lipophilic bioactive compound, is typically ingested orally for absorption into the human body. However, dynamically tracking the interaction between lipophilic bioactive compounds and digestive enzymes remains a significant challenge in the study of lipophilic bioactive compounds' absorption, translocation, and metabolism within the gastrointestinal tract. The interaction between curcumin and lipase or trypsin was monitored in real time using an ordered porous layer interference (OPLI) system based on silica colloidal crystal (SCC) films. The trypsin or lipase layers were obtained by adsorbing trypsin or lipase onto the SCC films. The optical thickness (OT) received by the OPLI system was used to monitor the interaction between curcumin and digestive enzymes in real time. By comparing the interaction processes of curcumin on trypsin layers at different pH values, it was determined that the structure of curcumin under varying pH conditions influenced its interaction with trypsin. The results for changes in optical thickness (ΔOT) showed that the ΔOT of curcumin was greater in the trypsin (24.79 ± 4.94 nm) than in the lipase (2.49 ± 0.84 nm). The combination or dissociation rate constant (
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