ReviewFrontiers in immunology2026
Phytochemical basis and antitumor mechanisms of
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Objective: This review aims to systematically evaluate the antineoplastic properties of PCL by integrating its phytochemical constituents with underlying pharmacological mechanisms and reported clinical relevance, thereby supporting its translational development. Methods: A comprehensive narrative review was performed using PubMed, Google Scholar, Web of Science, and CNKI to identify studies published from 2010 to August 2026. Evidence from Results: The principal bioactive constituents, including coumarins, flavonoids, and monoterpenoids, demonstrated several anticancer effects. These compounds exerted synergistic effects through multiple mechanisms, such as promoting apoptosis and cell cycle arrest, inhibiting metastatic progression, attenuating multidrug resistance, modulating the tumor immune microenvironment, and altering cellular metabolism. Additionally, the balance between therapeutic efficacy and potential toxicity, particularly hepatotoxicity, is critically discussed, alongside current strategies, including nanotechnology-based delivery systems and combinatorial herbal approaches, designed to improve therapeutic performance. Conclusion: PCL represents a multi-target botanical candidate with potential utility in adjuvant cancer therapy. Future studies are required to clarify synergistic interactions, optimize delivery strategies, and support rigorous clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.