ArticleJGH open : an open access journal of gastroenterology and hepatology2026
Current Status of Pancreatic Exocrine Insufficiency Diagnosis and Pancreatic Enzyme Replacement Therapy Implementation in Patients With Chronic Pancreatitis.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: The prevalence of chronic pancreatitis (CP) is increasing in Japan. This study aimed to elucidate the current status of pancreatic exocrine insufficiency (PEI) diagnosis and the prescription of pancreatic enzyme replacement therapy (PERT) in Japanese patients with CP. Methods: We conducted a retrospective observational study using a large-scale claims database in Japan with a data collection period between April 2008 and August 2022. Patients with CP were categorized into PERT and no-PERT cohorts based on the presence or absence of PERT prescriptions. Results: We found an increase in the number of CP diagnoses, PERT prescriptions, and PEI diagnoses over the past decade. The median PERT persistence time was 254.0 days (95% confidence interval: 219.0-288.0), and the 5-year persistence rate was 20.4%. Patients in the PERT cohort ( Conclusion: The number of PEI diagnoses and PERT prescriptions for patients with CP has increased in Japan over the past decade. The low PERT persistence rate suggests the need for further research to understand the factors that affect treatment persistence in CP management.
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