Evidence map›Paper›PMID 42819705›Full record

ArticleResearch (Washington, D.C.)2026

Astrocytic Sirt2-Mediated Delactylation Limits Blood-Spinal Cord Barrier Reconstruction after Spinal Cord Injury.

Yixue Hu, Hao Hu, Zhonghan Wu, Yiyang Mu, Zeqiang Chen, Linhan Yang, Mengdi Zhang, Zihao Chen, Zhenyu Zhang, Ziyu Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yixue HuDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0007-9972-1615
Hao HuDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0007-3309-4495
Zhonghan WuDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0000-0002-5927-5514
Yiyang MuDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0000-0002-2781-769X
Zeqiang ChenDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0003-5585-7474
Linhan YangDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0004-6426-6921
Mengdi ZhangDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0004-9738-7957
Zihao ChenDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0007-6878-1607
Zhenyu ZhangDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0004-4412-4088
Ziyu LiDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0000-0001-6694-8820
Fei YaoDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0001-0031-3969
Shuisheng YuDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0000-0002-1071-9903
Dasheng TianDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0000-6888-5640
Li ChengDepartment of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0000-0001-7928-4170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restoration of the blood-spinal cord barrier (BSCB) is required for substantial neurological improvement after spinal cord injury (SCI). Astrocytes are integral to this barrier and, after injury, undergo glycolytic adaptation accompanied by lactate accumulation. Whether a lactate-linked modification program in astrocytes participates in BSCB repair has remained unresolved. Here, we identify astrocytic delactylation as a brake on BSCB repair. Sirtuin2 (Sirt2), a delactylase, was strongly induced in astrocytes at the lesion border, and its expression paralleled the pathological expansion of microvessels. Selective deletion of

Identifiers

PMID42819705
PMCPMC13624570

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.