ArticleCureus2026
Valentino Syndrome With Histologically Confirmed Acute Appendicitis: A Rare Dual Pathology.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Acute abdomen is a common surgical emergency with multiple etiologies; acute appendicitis and perforated peptic ulcer (PPU) are among the common. Valentino's syndrome is a rare condition in which patients with PPU present with clinical features of acute appendicitis due to the flow of gastric contents along the right paracolic gutter, causing inflammation of the appendix. Diagnosis is often delayed and made during surgery. We discuss a case of a 25-year-old male who presented with acute pain in the right lower quadrant. Initial assessment pointed toward acute appendicitis; however, on further evaluation, the patient was found to have a perforated prepyloric ulcer with 500 mL of seropurulent peritoneal fluid and an inflamed appendix. He underwent Graham's patch repair of the prepyloric ulcer along with peritoneal lavage and appendectomy. Histopathology of the appendix revealed features suggestive of acute appendicitis, and biopsy from the prepyloric ulcer revealed an active ulcer with few
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