ArticlePakistan journal of medical sciences2026
Diagnostic Value of ANA Titer, Anti-ds-DNA, Anti-nRNPSm, and Sm Antibodies in Early Atypical Systemic Lupus Erythematosus.
Article in Pakistan journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the diagnostic value of antinuclear antibody(ANA) titer, anti-double-stranded DNA(anti-ds-DNA) antibody, anti-nuclear ribonucleoprotein/Smith(anti-nRNPSm) antibody, and Smith (Sm) antibody for early atypical systemic lupus erythematosus(SLE). Methodology: This was a retrospective study. Forty-nine patients diagnosed with early atypical SLE admitted to Affiliated Hospital of Hebei University between January 2023 to June 2025 were assigned to Group-A, and 66 patients with other autoimmune diseases admitted during the same period were enrolled in Group-B. Compared the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibody tests between the two groups, and analyzed the diagnostic value of the individual indicators and their combined detection for early atypical SLE. Results: There were statistically significant differences in the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies between the two groups(P<0.05). Multivariate Logistic regression analysis confirmed that ANA, anti-ds-DNA, anti-nRNPSm and Sm were independent influencing factors for early atypical SLE ( Conclusion: ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies are major independent influencing factors for early atypical SLE. Combined detection of these indicators may effectively improve the diagnostic value for this disease.
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