ArticlePakistan journal of medical sciences2026
Impact of a Mobile Health Application on Medication Adherence, Thyroid Function, and Quality of Life in Patients with Hypothyroidism: A Prospective Comparative Study.
Article in Pakistan journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background & Objective: Effective hypothyroidism management requires consistent daily levothyroxine therapy; poor adherence causes fluctuating Thyroid Stimulating Hormone (TSH), persistent symptoms, and long-term complications. To evaluate the impact of a mobile application on symptom improvement and clinical outcomes through improved treatment adherence among patients with hypothyroidism. Methodology: The study was conducted at the Outpatient Department of Diabetes & Endocrine center, Karachi over a duration of 10 months from 1 Results: Mobile app users showed lower mean TSH levels (4.0 ± 2.10 mIU/L) than non-users (6.78 ± 2.78 mIU/L; p < 0.001) and higher quality-of-life scores (82.43 ± 18.25 vs. 72.10 ± 21.64; p<0.01) at six months. The symptoms improvements were more pronounced in application users as compared to non- users especially in menstrual irregularity (40.0% vs. 70.0%; p < 0.001), fatigue (50.0% vs. 66.6%; p = 0.01) and weight gain (16.6% vs. 60%, p<0.01). Conclusion: The study revealed that integrating mobile health applications into routine hypothyroidism care can substantially enhance treatment outcomes and provide a simple and effective strategy for medication adherence.
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