ArticleJournal of the Endocrine Society2026
The effect of time-restricted eating accompanied by weight loss on thyroid function in adults with type 2 diabetes.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Context: Time-restricted eating (TRE) is a lifestyle intervention associated with beneficial cardiometabolic effects. The impact of TRE-induced weight reduction on thyroid hormonal responses is not well elucidated. Objective: To evaluate the effects of TRE accompanied by weight loss on thyroid function in adults with obesity and type 2 diabetes (T2DM). Methods: We performed an exploratory analysis of a randomized, crossover, open-label study in adults with obesity and T2DM who underwent 2 dietary interventions: TRE and standard lifestyle. Each intervention period lasted 6 weeks. Thyroid function was assessed by TSH, free T4 (fT4), free T3 (fT3), and reverse T3 (rT3). Results: Thirty-nine participants without known thyroid disease (age 56.3 years, 35.9% male, body mass index 32.4 ± 5.7 kg/m Conclusion: Despite inducing significant weight loss, TRE did not exert a significant effect on thyroid function in individuals with obesity and early T2DM.
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