Trial reportClinical interventions in aging2026
Short-Term Audiometric Trajectories in Older Adults Receiving Systemic Human Umbilical Cord-Derived Mesenchymal Stem Cells: An Exploratory Single-Arm Substudy.
Trial report in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To describe short-term longitudinal audiologic outcomes after systemic administration of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in older adults with vascular aging. Patients and Methods: This exploratory, single-arm audiologic substudy was embedded within a nonrandomized interventional parent trial of hUC-MSC administration for vascular aging. Participants were aged 60 to 80 years and met the parent study's prespecified eligibility criteria. Audiometric outcomes were assessed repeatedly at baseline and on days 30, 90, and 180 after the first infusion. The primary exploratory audiologic outcome was the ear-level change from baseline to day 90 in the 4-frequency pure-tone average (PTA-4; 0.5, 1, 2, and 4 kHz), with negative values indicating lower hearing thresholds at follow-up. Mean changes were estimated using a linear mixed-effects model for repeated measures. Results: Of 107 treated participants, 93 entered the hearing substudy (47 men [50.5%] and 46 women [49.5%]; mean [SD] age, 68.7 [5.1] years). After ear-level exclusions, 176 eligible ears from 91 participants comprised the analysis set. At day 90, 156 ears from 81 participants were evaluable. The model-estimated mean change in PTA-4 from baseline to day 90 was -0.77 dB HL (95% CI, -1.52 to -0.02). Among evaluable ears, the observed mean change from baseline to day 90 was -0.75 dB HL (95% CI, -1.52 to 0.02). Both estimates were less than 1 dB in magnitude and small relative to reported short-term audiometric test-retest variability. At days 30, 90, and 180, 97.2%, 95.5%, and 96.3% of evaluable ears, respectively, remained within the prespecified ±10-dB stability range. Conclusion: In this exploratory single-arm substudy, mean PTA-4 changed little over short-term follow-up, and most evaluable ears remained within the prespecified stability range. Without a concurrent audiologic comparator, the observed trajectory cannot be attributed causally to hUC-MSC administration. These data may inform future controlled studies. Parent Trial Registration: Chinese Clinical Trial Registry Identifier: ChiCTR2500101200; registered on April 22, 2025.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.