Evidence map›Paper›PMID 42819494›Full record

ArticlePrecision chemistry2026

A Support-Free Strategy to Synthesize Sequence-Defined Macromolecules Using Solvent-Resistant Nanofiltration.

Zahra Bozorgmehr, Janine Peeters, Wout Milis, Laurens A J Rutgeerts, Nezha Badi, Xiaoyu Tan, Cédric Van Goethem, Sareh Rezaei Hosseinabadi, Filip E Du Prez, Guy Koeckelberghs and 1 more

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Article in Precision chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zahra BozorgmehrMembrane Technology Group, cMACS Division, Faculty of Bioscience Engineering, KU Leuven, Celestijnenlaan 200F, Box 2454, 3001 Leuven, Belgium.
Janine PeetersDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, Box 2404, 3001 Leuven, Belgium.
Wout MilisDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, Box 2404, 3001 Leuven, Belgium.
Laurens A J RutgeertsMembrane Technology Group, cMACS Division, Faculty of Bioscience Engineering, KU Leuven, Celestijnenlaan 200F, Box 2454, 3001 Leuven, Belgium.ORCID https://orcid.org/0000-0002-1809-3722
Nezha BadiPolymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Departement of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium.ORCID https://orcid.org/0000-0003-4220-571X
Xiaoyu TanMembrane Technology Group, cMACS Division, Faculty of Bioscience Engineering, KU Leuven, Celestijnenlaan 200F, Box 2454, 3001 Leuven, Belgium.ORCID https://orcid.org/0000-0001-7146-1718
Cédric Van GoethemMembrane Technology Group, cMACS Division, Faculty of Bioscience Engineering, KU Leuven, Celestijnenlaan 200F, Box 2454, 3001 Leuven, Belgium.
Sareh Rezaei HosseinabadiMembrane Technology Group, cMACS Division, Faculty of Bioscience Engineering, KU Leuven, Celestijnenlaan 200F, Box 2454, 3001 Leuven, Belgium.ORCID https://orcid.org/0000-0001-8487-8184
Filip E Du PrezPolymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Departement of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium.ORCID https://orcid.org/0000-0001-7727-4155
Guy KoeckelberghsDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, Box 2404, 3001 Leuven, Belgium.
Ivo F J VankelecomMembrane Technology Group, cMACS Division, Faculty of Bioscience Engineering, KU Leuven, Celestijnenlaan 200F, Box 2454, 3001 Leuven, Belgium.ORCID https://orcid.org/0000-0002-0104-9493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequence-defined macromolecules (SDMs) offer tremendous promise for critical applications like data storage, optoelectronics, or biomimetics, but their synthesis remains particularly challenging. A generic SDM synthesis strategy is reported now using a support-free orthogonal approach starting from single monomers to produce SDMs. The procedure does not require any support, protection, or deprotection steps, nor does it require solvent switches. Crucially, each reaction step is followed by purification using solvent-resistant nanofiltration to ensure product retention from the reaction mixture with the complete removal of impurities (excess reagents, catalyst, byproducts). The sharp molecular weight resolution of well-tuned epoxy-based membranes renders this strategy highly efficient and versatile, as proven here by applying varying reactions, monomer types, and sizes to prepare two different sequence-defined conjugated macromolecules (SDCMs). Demonstrating the effectiveness of these membrane separations to purify SDCMs across very diverse conditions thus highlights the transformative potential of advanced membrane technology for SDM synthesis. Overall, a robust foundation is provided for advancing SDM development from single monomers to complex, high-purity oligomers.

Indexed as

cross-linked polyimideepoxy-based top layerHorner−Wadsworth−Emmons couplingmembranesequence-defined macromoleculessupport-free oligomersSuzuki−Miyaura reactionthin-film composite membrane

Identifiers

PMID42819494
PMCPMC13625918

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.