ArticleInternational journal of nanomedicine2026
A Preliminary in-vitro Evaluation of Serum Capped Colloidal Silver Nanoparticles on Liver Cancer towards Development of Safe Personalized Nanomedicine.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Serum-capped silver nanoparticles (AgNPs), synthesized using naturally occurring serum proteins and reducing agents, represent a green nanotechnology platform with potential for safer and more selective therapy. This study compared the safety and anticancer efficacy of serum-capped AgNPs with polyvinyl alcohol (PVA)-capped AgNPs. Methods: Serum-capped AgNPs (~18 nm, zeta potential -8.9 mV) were synthesized from human serum and administered intravenously in mice (0.1 mL/dose). PVA-capped AgNPs of equivalent silver concentration served as controls. Effects were assessed in a mouse hepatoma model, WRL-68, and Hep-G2, two different liver-derived cell lines using histopathology, biochemical analysis, MTT assay, estimation of proliferative potential by cell cluster formation assay, scratch assay, and hexosamine assays. Results: Serum-capped AgNPs showed a wider safety margin and lower toxicity in mice and normal WRL-68 cells compared with PVA-capped AgNPs, while exhibiting stronger cytotoxicity against hepatoma and Hep-G2 cancer cells. Treated mice showed improved survival, and favorable histopathological and biochemical profiles indicated reduced systemic toxicity. In the hepatoma model, serum-capped AgNPs, cisplatin, and their combination demonstrated significant anticancer effects, with combination therapy showing the strongest response. Discussion: Serum-capped AgNPs provide a safer and more selective nanotherapeutic approach by enhancing compatibility with normal host cells while retaining potent anticancer activity. Serum-derived capping improves biological precision and reduces systemic toxicity compared with conventional AgNP formulations. These findings support further investigation of serum-capped AgNPs as potential broad-spectrum anticancer (and antimicrobial) agents and for future personalized nanomedicine applications.
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