Evidence map›Paper›PMID 42819429›Full record

ArticleGastro hep advances2026

Regulation and Function of Sox2 and CD44 Expression in the Stomach by Bone Morphogenetic Protein Signaling.

Andrea Todisco, Justin Colacino, Nicholas Lesniak, Lei Peng, Xuan Li, Tsutomu Takeda, Xia Wei, Maria Mao, Veronique Orian-Rousseau, Kathryn A Eaton

Abstract read
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In one paragraph

Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea TodiscoDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Justin ColacinoDepartment of Environmental Health Sciences/School of Public Health, University of Michigan, Ann Arbor, Michigan.
Nicholas LesniakDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Lei PengDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xuan LiDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tsutomu TakedaDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
Xia WeiDepartment of Gastroenterology, Hangzhou Chinese Medicine Hospital, Hangzhou, Zhejiang, China.
Maria MaoDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Veronique Orian-RousseauInstitute of Biological and Chemical Systems-Functional Molecular Systems, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Kathryn A EatonDepartment of Microbiology and Immunology, University of Michigan Medical Center, Ann Arbor, Michigan.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1986 to 2021
$22.5M
Diversity SupplementR01ES028802 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 2018 to 2026
$4.8M
Regulation of gastric metaplasia, dysplasia and neoplasia by Bone Morphogenetic Protein signalingR01DK121785 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TODISCO, ANDREA · 2020 to 2023
$1.8M
Targeting cancer stem-like cells and inflammation for colon cancer chemopreventionR21CA273646 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, GRACE Y., COLACINO, JUSTIN ADAM · 2023 to 2024
$392k
Regulation of gastric metaplasia, dysplasia and neoplasia by Bone Morphogenetic Protein signalingR56DK116617 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TODISCO, ANDREA · 2017 to 2017
$376k
NCI NIH HHS P30 CA046592NCI NIH HHS R21 CA273646NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK121785NIDDK NIH HHS R56 DK116617NIEHS NIH HHS R01 ES028802
6 · The paper itself

Abstract

Background and Aims: The transcription factor Sox2 and the adhesion molecule CD44 are implicated in gastric metaplasia and neoplasia. Lgr5 is a cellular receptor that marks gastric progenitors involved in epithelial homeostasis. We reported that inhibition of bone morphogenetic protein (BMP) signaling in the stomach activates aberrant cells that lead to spasmolytic polypeptide-expressing metaplasia (SPEM), a preneoplastic metaplasia. We investigated the role of BMP-regulated transcriptional programs in gastric metaplasia/SPEM and the localization and function of CD44 and Sox2 in the context of inhibition of BMP signaling. Methods: Deletion of Results: Sox2 Conclusion: Inhibition of BMP signaling affects gastric epithelial transcriptomes and cell plasticity, underscoring the relevance of this mechanism in the development of metaplasia and in the regulation of CD44 and Sox2.

Indexed as

Cell DifferentiationCell SignalingGene ExpressionRNA-Seq

Identifiers

PMID42819429
PMCPMC13625856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.