ReviewBiochemistry and biophysics reports2026
Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.
Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Major depressive disorder (MDD) is a heterogeneous psychiatric disorder involving oxidative stress, neuroinflammation, mitochondrial dysfunction, impaired neuroplasticity, and metabolic dysregulation. Ferroptosis, an iron-dependent form of regulated cell death driven by phospholipid peroxidation and antioxidant defense failure, has recently attracted attention as a potential mechanism linking these pathological processes. This review summarizes the molecular basis of ferroptosis in MDD, focusing on iron dyshomeostasis, lipid peroxidation, and disruption of the System Xc
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