ArticleFrontiers in aging neuroscience2026
Gait performance in cerebral small vessel disease: associations with cognitive and oculomotor function and exploratory mediation analyses.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Gait impairment in cerebral small vessel disease (CSVD) is heterogeneous and may not be fully explained by conventional structural MRI markers. We investigated the associations of neuroimaging burden, cognitive function, and oculomotor function with gait performance in CSVD and explored potential indirect associations between CSVD burden and gait impairment. Methods: We included 65 individuals with CSVD and 35 control participants. All participants underwent quantitative gait assessment, standardized neuropsychological evaluation, and oculomotor recording. Patients with and without gait disorder were compared after adjustment for the total CSVD load score. Correlation analyses assessed associations among neuroimaging markers, cognitive and oculomotor measures, and gait parameters. Exploratory mediation analyses examined cognitive and oculomotor measures as potential statistical indirect pathways between total CSVD load and gait performance. Results: Compared with control participants, patients with CSVD had poorer gait, cognitive, and oculomotor performance ( Conclusions: Executive and oculomotor dysfunction were associated with gait impairment in CSVD and may partly account for the association between total CSVD burden and gait performance. These exploratory findings require confirmation in larger longitudinal studies.
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