Evidence map›Paper›PMID 42819408›Full record

ArticleAmerican journal of ophthalmology case reports2026

Recovery course of photoreceptor damage in a patient with cat scratch disease neuroretinitis: 2.5-year observation using adaptive optics retinal imaging.

Reina Aoyama, Daiki Sakai, Shin-Ichiro Ito, Wataru Matsumiya, Midori Yamamoto, Kiyoko Gocho, Sunao Sugita, Makoto Nakamura, Yasuo Kurimoto

Abstract readCase Reports
In one paragraph

Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Reina AoyamaDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Daiki SakaiDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Shin-Ichiro ItoDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Wataru MatsumiyaDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
Midori YamamotoDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Kiyoko GochoDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Sunao SugitaDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Makoto NakamuraDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yasuo KurimotoDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To assess the course of retinal damage in neuroretinitis associated with cat-scratch disease from the acute treatment phase to long-term follow-up. Observations: A 29-year-old female diagnosed with seropositive cat-scratch disease neuroretinitis. At the initial visit, her right eye (OD) presented with decreased visual acuity (best-corrected decimal visual acuity, 0.8) and a central scotoma, along with hyperemic swelling of the optic disc, serous retinal detachment, and stellate maculopathy. Treatment with oral clarithromycin and oral prednisolone, starting with 30 mg daily and then tapered, led to complete resolution of these findings within 9 months. An adaptive optics retinal camera (rtx1™) revealed a disrupted photoreceptor mosaic corresponding to a post-detached retinal area, patchy dark spots in the papillomacular bundle, and hyperreflective deposits corresponding to stellate maculopathy. The dark spots and hyperreflective deposits diminished within one year. While photoreceptor mosaic disruption, correlated with disruption of interdigitation zone on OCT, showed gradual improvement, abnormal findings persisted in the papillomacular bundle even at 2.5 years. At the final follow-up, OD cone density remained at 84.7% of OS cone density in the macular temporal region (5° from fovea) (OD: 14,625/mm Conclusion: Long-term persistence of photoreceptor damage, even after visual recovery, may occur in cat-scratch disease neuroretinitis even after systemic antibiotic and anti-inflammatory therapies. Adaptive optics imaging is a useful tool for careful observation.

Indexed as

Adaptive opticsCat scratch diseaseCone densityNeuroretinitisOptical coherence tomographyPhotoreceptorUveitis

Identifiers

PMID42819408
PMCPMC13625793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.