Evidence map›Paper›PMID 42819394›Full record

ArticleSleep medicine: X2026

Effects of CPAP withdrawal on sex hormone levels in patients with obstructive sleep apnoea: data from two randomised, controlled trials.

Fabian A Grewe, Sira Thiel, Sarah R Haile, Mirko Peitzsch, Esther I Schwarz, Noriane A Sievi, Felix Beuschlein, Malcolm Kohler, Thomas Gaisl

Abstract read
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In one paragraph

Article in Sleep medicine: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fabian A GreweDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sira ThielDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sarah R HaileDepartment of Epidemiology, Epidemiology, Biostatistics, and Prevention Institute, University of Zurich, Zurich, Switzerland.
Mirko PeitzschInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Esther I SchwarzDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Noriane A SieviDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Felix BeuschleinDepartment of Endocrinology and Diabetology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Malcolm KohlerCentre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
Thomas GaislDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sexual dysfunction (SD) is common in patients with obstructive sleep apnoea (OSA). Although continuous positive airway pressure (CPAP) therapy improves SD, it does not consistently modify testosterone or estradiol levels, suggesting involvement of other hormonal pathways. We analysed sex hormone levels in 70 patients with OSA before and after two weeks of CPAP withdrawal. No statistically significant treatment effects were observed for testosterone, androstenedione, gestagens, dehydroepiandrosterone sulfate, luteinizing hormone or follicle-stimulating hormone, whereas dehydroepiandrosterone (DHEA) increased after CPAP withdrawal. As DHEA secretion is adrenocorticotropic hormone-responsive, this increase may point to stress-related mechanisms, rather than direct sex steroid-mediated pathways, as potential contributors to OSA-related SD.

Indexed as

Continuous positive airway pressureObstructive sleep apnoeaSex hormonesSexual dysfunction

Identifiers

PMID42819394
PMCPMC13625797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.