Evidence map›Paper›PMID 42819317›Full record

ArticleFrontiers in immunology2026

Neutrophil extracellular traps promote lung colonization of triple-negative breast cancer by inducing mesenchymal to epithelial transition.

Taiko Kawakami, Yusuke Nakanishi, Akari Suzuki, Kazuhiko Yamamoto, Kyoko Takahashi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taiko Kawakami *College of Bioresource Sciences, Graduate School of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Yusuke Nakanishi *College of Bioresource Sciences, Graduate School of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Akari SuzukiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Kazuhiko YamamotoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Kyoko TakahashiCollege of Bioresource Sciences, Graduate School of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic recurrence is still a major problem for triple-negative breast cancer (TNBC). Neutrophil extracellular traps (NETs) in the pulmonary microenvironment are known to play key roles in the metastatic colonization and outgrowth of TNBC. However, the exact role that NETs play in determining the phenotypic plasticity and reactivation of disseminated tumor cells (DTCs) during acute relapse remains unclear. Here, we utilized an orthotopic, acute recurrent metastasis mouse model by transplanting 4T1 cells into wild-type or NET-deficient (

Indexed as

Epithelial-Mesenchymal TransitionExtracellular TrapsLung NeoplasmsNeutrophilsTriple Negative Breast NeoplasmsAnimalsCell Line, TumorFemaleHumansMiceMice, KnockoutProtein-Arginine Deiminase Type 4Transforming Growth Factor betaTumor Microenvironmentpeptidylarginine deiminase 4, mouseProtein-Arginine Deiminase Type 4Transforming Growth Factor betamesenchymal epithelial transition (MET)metastasisneutrophil extracellular traps (NETs)TGF-β signalingtumor microenvironment

Identifiers

PMID42819317
PMCPMC13623897

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.