ArticleFrontiers in public health2026
Psychosocial and mental health outcomes associated with gender-affirming interventions among transgender youth: a scoping review.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Introduction: Transgender youth are a highly vulnerabilized population, facing stigma, discrimination, family rejection, and social exclusion that elevate their risk of depression, anxiety, and suicidal ideation. Gender-affirming interventions-medical, psychological, social, and structural-have been proposed to improve health and wellbeing in this group, but evidence on their psychosocial and mental health impact remains scattered across heterogeneous contexts and intervention types. This scoping review aimed to map and synthesize available evidence on psychosocial and mental health outcomes associated with gender-affirming interventions among transgender youth. Methods: Following JBI methodology and the PRISMA-ScR checklist, we searched PubMed, Scopus, Embase, Web of Science, and CINAHL in August 2025 for peer-reviewed, English-language articles published between January 2011 and July 2025. Eligible studies addressed gender-affirming interventions or experiences among transgender and gender-diverse individuals and reported psychosocial or mental health outcomes. Results: Of 1,207 records identified, 17 studies met eligibility criteria, comprising 123,428 participants (range: 15-120,617 per study). Designs included prospective cohort ( Conclusion: Gender-affirming interventions are associated with improved psychosocial and mental health outcomes among transgender youth, but optimal wellbeing depends on more than medical intervention alone, requiring family support, inclusive education, affirmative healthcare systems, and supportive policy. Substantial gaps remain for non-Western, low- and middle-income, and non-binary/gender-diverse populations, highlighting the need for research testing whether existing frameworks translate across sociocultural contexts.
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