Trial reportFrontiers in public health2026
A 12-month structured exercise reduces epicardial adipose volume in a frequency-dependent manner and lowers serum M-CSF in community-dwelling older adults: a randomized controlled trial.
Trial report in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Exercise is a well-established strategy for promoting healthy aging and reducing cardiometabolic risk; however, its effects on epicardial adipose volume (EAV) and associated inflammatory pathways in older adults remain insufficiently understood. This randomized controlled trial examined whether a 12-month structured exercise program reduces EAV in community-dwelling older adults, and secondarily explored changes in serum pro-inflammatory cytokines. Methods: This single-center pragmatic randomized controlled trial incorporated a Zelen design. A total of 156 older adults (≥60 years) were evenly allocated to a structured exercise (STE) group or a control group. The control group received health education only; the STE group performed one supervised center-based session plus at least two home-based sessions per week, with matched intensity and duration. EAV, body fat parameters, and circulating pro-inflammatory factors were measured at baseline and after 12 months. Results: Among the randomized participants, 57 individuals in the control group and 61 individuals in the STE group completed the 12-month follow-up (55 men, 46.6%; mean age 69.17 ± 4.41 years). The absolute EAV change differed significantly between groups (STE vs. control: -15.15 mL, 95% CI -22.61 to -7.69, Conclusion: A 12-month structured exercise intervention was associated with reduced EAV and lower circulating M-CSF levels in community-dwelling older adults, with greater reductions observed among participants engaging in more frequent weekly exercise sessions. These findings support regular supervised exercise as a non-pharmacological strategy to reduce cardiac adiposity and modulate inflammation in aging populations. Clinical trial registration: https://www.chictr.org.cn/indexEN.html, ChiCTR2400081824.
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