ArticleFrontiers in endocrinology2026
Integrative multi-omics analysis unveils the regulatory landscape of diabetic cardiomyopathy: from chromatin accessibility to transcript isoforms and epitranscriptome.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetic cardiomyopathy (DCM) is a major contributor to heart failure in diabetic patients, characterized by profound metabolic remodeling and diastolic dysfunction. However, the multi-layered epitranscriptomic and post-transcriptional networks involved in this disease remain poorly understood. To address this, we established a type 2 diabetes-associated DCM mouse model using a high-fat diet (HFD) combined with low-dose streptozotocin (STZ) injections. By integrating single-molecule direct RNA sequencing (DRS-seq), chromatin accessibility profiling (ATAC-seq), and conventional bulk RNA-seq, we constructed a comprehensive epigenetic-transcriptional regulatory map of DCM. Using DRS-seq, we identified 21,156 full-length transcripts, including 8,457 (39.97%) novel unannotated isoforms, and observed a systemic 3'-UTR elongation under diabetic stress. Joint ATAC-seq and DRS-seq analysis identified concurrent reductions in promoter chromatin accessibility and transcript abundance for four genes, including
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