ArticleFrontiers in physiology2026
Acute liver failure induced by hepatitis E virus complicated with pancreatitis and refractory acute respiratory distress syndrome after rapid ascent to high altitude: a case report and literature review.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute respiratory distress syndrome (ARDS) and pancreatitis are fatal extrahepatic complication of hepatitis E virus (HEV)-induced acute liver failure (ALF). High-altitude hypobaric hypoxia may exacerbate pulmonary endothelial injury and delay tissue repair, but its impact on the severity and reversibility of ALF-related pancreatitis and ARDS remain uncharacterized. Case presentation: A 44-year-old male (Body mass index 31.7 kg/m Conclusion: Sustained high-altitude hypoxia may contribute to refractoriness and delayed recovery of ALF-related ARDS. Altitude descent may be a valuable adjuvant strategy for hemodynamically stable patients with refractory hypoxemia, pending further prospective validation.
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