Synthesis of the Natural Product Berberine.

Hongyu Song, Baozhao Lu, Congdi Chen, Guoquan Yang, Hongjun Yang

Abstract read

In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hongyu SongKey Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China.

Baozhao LuKey Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China.

Congdi ChenCollege of Chemistry and Life Science, Chengdu Normal University, Chengdu 611130, China.

Guoquan YangKey Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China.

Hongjun YangKey Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China.ORCID https://orcid.org/0000-0002-4594-0595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, the synthesis of berberine was accomplished through three distinct routes. The key innovation lies in replacing the traditional intermediate piperonylamine with 2,3-dimethoxybenzylamine, thereby circumventing the lengthy and low-yielding steps of the intermediate. The newly developed routes are characterized by short synthetic sequences and by overall yields of 22.6-32.8% for berberine. Moreover, the starting materials are inexpensive, readily available, and derived from natural sources. Notably, in contrast to previously reported routes, route

Identifiers

PMID42819165

DOI10.1021/acsomega.6c06067

PMCPMC13625137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.