ArticleFrontiers in medicine2026
Sex-specific associations of urinary N-acetyl-
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Introduction: Urinary N-acetyl-β-D-glucosaminidase (uNAG), a sensitive biomarker of renal tubular injury, has been linked to vascular pathology through oxidative stress, inflammation, and endothelial dysfunction. However, sex-specific associations between uNAG and early vascular damage remain unclear. Methods: This cross-sectional study included 2,621 adults undergoing routine health examinations. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV), with increased arterial stiffness defined as a mean baPWV >1,700 cm/s. uNAG and baPWV were measured using standardized protocols. Sex-stratified logistic regression analyses were performed. Results: In men, participants in the highest uNAG tertile had more than twofold higher adjusted odds of increased arterial stiffness after adjustment for age, mean arterial pressure, antihypertensive medication use, fasting glucose, triglycerides, and LDL-C (OR, 2.372; 95% CI, 1.603-3.510; Discussion: Elevated uNAG was more strongly associated with increased arterial stiffness in men than in women, suggesting sex-related effect modification. Because of the cross-sectional design, these findings indicate associations rather than causal relationships.
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