SynthesisFrontiers in dental medicine2026
Effect of probiotic interventions on oral health in children: a systematic review.
Synthesis in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Introduction: Early childhood caries (ECC) is one of the most prevalent chronic diseases affecting young children worldwide. Probiotic supplementation has emerged as a potential adjunctive strategy for modifying the oral microbiome and reducing caries risk; however, evidence regarding its effectiveness remains inconsistent. This review evaluated the effects of probiotic interventions on oral health outcomes in children under 6 years of age, with emphasis on probiotic-based interventions and their influence on caries incidence, microbial changes, and biological mechanisms. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted in accordance with the PRISMA 2020 guidelines up to June 2026. Eligible studies included randomized controlled trials, non-randomized intervention studies, and Results: Twenty-one studies met the inclusion criteria, comprising 13 randomized controlled trials, three non-randomized intervention studies, and five Conclusion: Probiotic supplementation appears to be a promising adjunct to conventional preventive strategies for improving oral microbial profiles and reducing caries progression in preschool children. However, the observed benefits appear to be strain-specific, and considerable heterogeneity across interventions and outcome measures limits definitive clinical recommendations. Further high-quality, adequately powered randomized controlled trials with standardized probiotic regimens, uniform caries assessment. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251229276, PROSPERO CRD420251229276.
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