Evidence map›Paper›PMID 42818985›Full record

ArticleResearch square2026

Genetic associations with alcohol drinking initiation and cessation in sub-Saharan African and African ancestry populations.

Jean-Tristan Brandenburg, Ritah Nabunje, Opeyemi Soremekun, Wenlong Carl Chen, Dylan Kerrigan, Christopher G Mathew, Martin D Tobin, Tinashe Chikowore, Segun Fatumo, Michèle Ramsay and 2 more

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In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jean-Tristan BrandenburgSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand.
Ritah NabunjeGenomic Epidemiology and Public Health / Genomic Diversity Research Group, MRC/UVRI & LSHTM Uganda Research Unit.
Opeyemi SoremekunGenomic Epidemiology and Public Health / Genomic Diversity Research Group, MRC/UVRI & LSHTM Uganda Research Unit.
Wenlong Carl ChenSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand.
Dylan KerriganSchool of Criminology, Sociology and Social Policy, University of Leicester.
Christopher G MathewSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand.
Martin D TobinDivision of Public Health and Epidemiology, School of Medical Sciences, University of Leicester.
Tinashe ChikoworeSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand.
Segun FatumoGenomic Epidemiology and Public Health / Genomic Diversity Research Group, MRC/UVRI & LSHTM Uganda Research Unit.
Michèle RamsaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand.
Chiara BatiniDivision of Public Health and Epidemiology, School of Medical Sciences, University of Leicester.
Palwendé Romuald BouaClinical Research Unit Nanoro, Institut de Recherche en Sciences de la Santé.

Funding

Shared Core: Biobanking, Bioinformatics and Data ManagementU54HG006938 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI RAMSAY, MICHELE MICHELE · 2012 to 2022
$12.2M
NHGRI NIH HHS U54 HG006938Wellcome Trust
6 · The paper itself

Abstract

Alcohol misuse is a major global health concern with significant genetic contributions, yet studies in African populations remain limited. We conducted genome-wide association meta-analyses for alcohol drinking initiation and cessation across multiple cohorts comprising individuals from sub-Saharan Africa (N = 20,936) and those with African ancestry from UK Biobank (N = 7,726). Our analyses identified two genome-wide significant loci associated with drinking cessation (

Indexed as

African ancestryAlcohol drinking cessationAlcohol drinking initiationAlcohol useGenome-wide association study (GWAS)Sub-Saharan Africa

Identifiers

PMID42818985
PMCPMC13622846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.