ArticleStem cells international2026
CD73-Overexpressing ADSCs Promote Neurogenic Bladder Repair via A2A-JAK1/STAT3-Mediated Modulation of Inflammation and Macrophage Polarization.
Article in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neurogenic bladder (NB) is characterized by chronic inflammation and bladder tissue injury, and current treatments fail to restore the inflammatory microenvironment or tissue integrity. Although adipose-derived stem cell (ADSC) therapy shows regenerative potential, its efficacy is limited by inflammation; whether CD73 overexpression enhances ADSC therapeutic effects in NB remains unclear. Methods: A rat model of NB was established via pelvic nerve (PN) injury and treated with CD73-overexpressing ADSCs (CD73 Results: CD73 Conclusion: Our findings suggest that CD73 contributes to the immunomodulatory and reparative properties of ADSCs under inflammatory conditions. By coordinating adenosinergic signaling, inflammatory suppression, and repair-associated pathways, CD73
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