ArticleJGH open : an open access journal of gastroenterology and hepatology2026
Five-Year CT-Based Skeletal Muscle Decline Curves in Cirrhosis According to Liver Functional Reserve and Routinely Available Clinical Factors.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sarcopenia is common in cirrhosis and is associated with poor outcomes. We aimed to identify factors associated with longitudinal skeletal muscle loss and to explore estimation of future L3 skeletal muscle index (L3-SMI) using routinely available clinical variables. Methods: This retrospective longitudinal study included 175 patients with cirrhosis who underwent serial abdominal CT over five annual time points between 2010 and 2022. The primary analysis used a linear mixed-effects model including annual time point, baseline Child-Pugh class, and their interaction. An exploratory linear regression model estimated Year 5 L3-SMI. Results: In the primary model, L3-SMI declined by -1.144 cm Conclusions: Baseline hepatic functional reserve, particularly Child-Pugh class C, was associated with faster annual CT-based L3-SMI decline. The Year 5 prediction model is exploratory and requires external validation. Early sarcopenia assessment may facilitate risk stratification in patients with impaired hepatic reserve.
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