ArticlePakistan journal of medical sciences2026
Analysis of clinical and heart rate variability parameters associated with single-vessel and multivessel coronary artery disease: A retrospective study.
Article in Pakistan journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To compare heart rate variability (HRV) parameters and cardiac biomarkers between patients with single-vessel and multivessel coronary artery disease (CAD) and assess their associations with multivessel involvement. Methodology: This retrospective study included 196 patients with angiographically confirmed CAD admitted between September 2022 and May 2025 at Ningguo People's Hospital. Patients were classified as having single-vessel (n=55) or multivessel (n=141) disease. Group differences were assessed, and logistic regression was used to examine associations of SDNN, deceleration capacity (DC), high-sensitivity cardiac troponin T (hs-TnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) with multivessel disease. Restricted cubic spline analysis explored potential nonlinear relationships. Results: The multivessel group had lower SDNN, SDANN, SDNN index, and DC and higher hs-TnT and NT-proBNP levels than the single-vessel group (all P<0.05). After adjustment for age, sex, hypertension, and diabetes, higher SDNN was associated with lower odds of multivessel disease (OR=0.68, 95% CI: 0.49-0.94), whereas higher hs-TnT (OR=2.43, 95% CI: 1.35-4.37) and NT-proBNP (OR=3.51, 95% CI: 1.28-9.62) were associated with higher odds. DC was not significantly associated with multivessel disease. Spline analyses suggested possible nonlinear patterns for SDNN and DC, but these findings were exploratory. Conclusion: Lower SDNN and higher hs-TnT and NT-proBNP were associated with multivessel CAD. The hs-TnT finding should be interpreted in the context of myocardial injury burden and limited control of confounding.
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