ArticleResearch square2026
Evolution of MAF and OTX families during the emergence and stabilization of rod photoreceptors across Metazoans.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
A central question in evolutionary developmental biology is how gene regulatory networks are rewired to generate new cell types. In mammals, rod specification and maintenance depend on the MAF-family transcription factor NRL; yet, non-mammalian vertebrates also possess NRL-independent rods, suggesting that alternative regulatory mechanisms may underlie rod evolution across lineages. Here, we investigate the evolutionary history and functional diversification of the MAF transcription factor family across metazoans. Phylogenetic and comparative genomic analyses reveal that large and small MAFs expanded through ancient duplication events, whereas the ancestral large and small
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